TB-Profiler

TB-Profiler result

Run: SRR6045033

This average coverage of the target regions is below the recommended 30x. Some mutations may not be detected due to low coverage.

Summary

Run ID: SRR6045033

Sample name:

Date: 2025-07-28T08:38:24.171829

Number of reads: 185417

Percentage reads mapped: 99.31

Median coverage: 4.0

Strain: lineage1.2.2.2

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs

Lineage	Family	RDs	Frequency
lineage1	Indo-Oceanic	RD239	100.0
lineage1.2.2	Indo-Oceanic	RD239	100.0
lineage1.2.2.2	Indo-Oceanic	RD239	100.0

Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes

Drug	Resistance	Supporting mutations	WHO confidence	Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid

Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence	Comment

Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence
fbiC	1302948	c.18T>G	synonymous_variant	1.0	clofazimine	Not assoc w R - Interim
					delamanid	Not assoc w R - Interim
					pretomanid	Uncertain significance
whiB6	4338732	c.-211C>T	upstream_gene_variant	1.0	amikacin	Uncertain significance
					capreomycin	Uncertain significance
					kanamycin	Uncertain significance