TB-Profiler result

Run: SRR13837629
Summary

Run ID: SRR13837629

Sample name:

Date: 2024-10-05T04:58:16.662133

Number of reads: 293892

Percentage reads mapped: 97.01

Median coverage: 10.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.9 Euro-American (H37Rv-like) None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
fgd1 490804 p.Tyr8Asn missense_variant 1.0 pretomanid
delamanid
clofazimine
fgd1 490893 c.111C>T synonymous_variant 1.0 pretomanid
delamanid
clofazimine
rpoC 763663 c.294C>A synonymous_variant 1.0 rifampicin
rpoC 765682 p.Asn771Lys missense_variant 0.93 rifampicin
Rv1129c 1254119 p.Ser139Phe missense_variant 1.0 levofloxacin
moxifloxacin
isoniazid
rifampicin
embR 1416509 p.Arg280Pro missense_variant 1.0 ethambutol
rrl 1474164 n.507C>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
katG 2154959 c.1153C>A synonymous_variant 1.0 isoniazid
pncA 2290061 c.-820C>T upstream_gene_variant 1.0 pyrazinamide
folC 2747798 c.-200A>T upstream_gene_variant 1.0 para-aminosalicylic_acid
Rv3083 3448855 p.Val118Ile missense_variant 1.0 ethionamide
mtrB 3626557 p.Met19Ile missense_variant 1.0 rifampicin
bedaquiline
rpoA 3877765 p.Ala248Gly missense_variant 1.0 rifampicin
panD 4044948 c.-667A>G upstream_gene_variant 1.0 pyrazinamide
embB 4247059 c.546C>G synonymous_variant 1.0 ethambutol
embB 4247144 p.Ser211Pro missense_variant 1.0 ethambutol
ubiA 4269553 p.Ala94Gly missense_variant 1.0 ethambutol