TB-Profiler result

Run: SRR11823427
Summary

Run ID: SRR11823427

Sample name:

Date: 2025-03-05T13:20:33.372192

Number of reads: 1358820

Percentage reads mapped: 99.97

Median coverage: 51.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.9 Euro-American (H37Rv-like) None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
Rv0010c 13824 c.-266A>T upstream_gene_variant 0.3 isoniazid Uncertain significance
Rv0010c 13829 c.-271T>A upstream_gene_variant 0.35 isoniazid Uncertain significance
Rv0010c 13834 c.-276A>T upstream_gene_variant 0.32 isoniazid Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rpsA 1833641 p.Asn34Asp missense_variant 0.2 pyrazinamide Uncertain significance
rpsA 1833648 p.Gly36Val missense_variant 0.25 pyrazinamide Uncertain significance
rpsA 1833651 p.Asp37Ala missense_variant 0.25 pyrazinamide Uncertain significance
rpsA 1833658 c.117C>T synonymous_variant 0.26 pyrazinamide Uncertain significance