TB-Profiler result

Run: SRR1175508
Summary

Run ID: SRR1175508

Sample name:

Date: 2024-04-15T00:30:15.337053

Number of reads: 95947

Percentage reads mapped: 9.56

Median coverage: 1.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 0.99
lineage4.9 Euro-American (H37Rv-like) None 0.99
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 822 c.822A>G synonymous_variant 0.91 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.91 isoniazid Not assoc w R - Interim
dnaA 837 c.837A>G synonymous_variant 0.9 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.9 isoniazid
dnaA 846 c.846T>C synonymous_variant 0.9 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.9 isoniazid
dnaA 852 c.852G>A synonymous_variant 0.91 isoniazid Not assoc w R - Interim
dnaA 885 c.885T>C synonymous_variant 0.91 isoniazid
dnaA 888 c.888C>G synonymous_variant 0.91 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.83 isoniazid
dnaA 903 c.903C>G synonymous_variant 0.91 isoniazid Not assoc w R - Interim
gyrB 6151 c.912C>T synonymous_variant 0.75 levofloxacin
moxifloxacin
gyrB 6172 c.933C>T synonymous_variant 0.75 levofloxacin
moxifloxacin
gyrB 6184 c.945C>T synonymous_variant 0.73 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6673 c.-629A>C upstream_gene_variant 0.91 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.91 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 6706 c.-596G>A upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 6727 c.-575G>T upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrB 6728 c.1489_1491delCTAinsTG frameshift_variant&stop_gained 1.0 levofloxacin Uncertain significance
moxifloxacin
gyrA 6739 c.-563C>T upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrA 7511 c.210C>T synonymous_variant 0.9 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.92 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7526 c.225G>C synonymous_variant 0.92 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.95 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7553 c.252C>T synonymous_variant 0.9 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7559 c.258G>C synonymous_variant 0.91 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7565 c.264C>T synonymous_variant 0.95 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7574 c.273G>C synonymous_variant 0.86 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7589 c.288G>C synonymous_variant 0.89 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7595 c.294C>T synonymous_variant 0.88 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>T synonymous_variant 0.92 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8846 c.1545C>T synonymous_variant 0.91 levofloxacin
moxifloxacin
gyrA 8852 c.1551T>C synonymous_variant 0.91 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.86 levofloxacin
moxifloxacin
gyrA 8870 c.1569G>C synonymous_variant 0.85 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>G synonymous_variant 0.85 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
ccsA 620322 c.432G>C synonymous_variant 0.7 capreomycin
amikacin
kanamycin
ccsA 620328 c.438G>C synonymous_variant 0.77 capreomycin
amikacin
kanamycin
ccsA 620338 c.448_450delACCinsGG frameshift_variant&missense_variant 0.79 capreomycin
amikacin
kanamycin
ccsA 620349 c.459A>C synonymous_variant 0.8 capreomycin
amikacin
kanamycin
ccsA 620354 p.Trp155Tyr missense_variant 0.8 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.81 capreomycin
amikacin
kanamycin
ccsA 620365 p.Asn159Tyr missense_variant 0.81 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>C synonymous_variant 0.81 capreomycin
amikacin
kanamycin
ccsA 620397 c.507C>G synonymous_variant 0.81 capreomycin
amikacin
kanamycin
ccsA 620412 c.522T>C synonymous_variant 0.8 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.8 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rpoB 760181 c.375T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 760256 c.450C>T synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 760276 p.Lys157Met missense_variant 0.9 rifampicin Uncertain significance
rpoB 760430 c.624T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 760668 c.862_864delACGinsGC frameshift_variant&missense_variant 0.79 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 760858 p.Val351Ala missense_variant 0.9 rifampicin Uncertain significance
rpoB 760862 c.1056G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 760865 c.1059C>T synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 760886 p.Glu360Asp missense_variant 0.87 rifampicin Uncertain significance
rpoB 760887 p.Thr361Val missense_variant 0.87 rifampicin Uncertain significance
rpoB 760910 c.1104C>T synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 760916 c.1110C>T synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 760928 c.1122G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 760943 c.1137C>T synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 760946 c.1140A>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 760965 p.Met387Leu missense_variant 0.8 rifampicin Uncertain significance
rpoB 761015 c.1209G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 761084 c.1278C>A synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.86 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.86 rifampicin
rpoB 761105 c.1299C>T synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>T synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761612 c.1806G>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 762194 c.2388G>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 762236 c.2430G>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 762275 c.2469C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762284 c.2478G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762488 c.2682G>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 762491 c.2685T>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 762866 c.3060C>T synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 762879 p.Met1025Leu missense_variant 0.7 rifampicin Uncertain significance
rpoB 762959 c.3153G>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 763082 c.3276C>T synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 763088 c.3282C>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 763145 c.3339G>A synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 763157 c.3351G>T synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 763166 c.3360A>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 763172 c.3366G>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 763531 c.162G>T synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 763657 c.288G>A synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 764054 c.685C>T synonymous_variant 1.0 rifampicin
rpoC 764059 c.690G>T synonymous_variant 1.0 rifampicin
rpoC 764095 c.726C>T synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 764098 c.729A>G synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 764110 c.741C>T synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764377 c.1008C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 1.0 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCA frameshift_variant&missense_variant 0.88 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 764470 c.1101C>T synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764524 c.1155C>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 764530 c.1161C>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 764534 c.1165C>A synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>T synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764542 c.1173C>T synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764545 c.1176C>A synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 764560 c.1191T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 764692 c.1323C>T synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.94 rifampicin Not assoc w R
rpoC 764810 p.Pro481Ala missense_variant 0.94 rifampicin Uncertain significance
rpoC 764815 c.1446A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764887 c.1518G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 1.0 rifampicin
rpoC 764912 p.Met515Gln missense_variant 1.0 rifampicin Uncertain significance
rpoC 764932 c.1563C>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579_1581delTTGinsCC frameshift_variant&missense_variant 1.0 rifampicin
rpoC 764968 c.1599T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765421 c.2052C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 765861 p.Phe831Tyr missense_variant 0.8 rifampicin Uncertain significance
rpoC 765875 p.Val836Ile missense_variant 0.94 rifampicin Uncertain significance
rpoC 765907 c.2538G>T synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 765910 c.2541G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 765940 c.2571A>T synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 766549 c.3180G>C synonymous_variant 0.75 rifampicin
rpoC 766570 c.3201T>C synonymous_variant 0.69 rifampicin
rpoC 766573 c.3204T>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 766588 c.3219G>A synonymous_variant 0.75 rifampicin
rpoC 766594 c.3225G>T synonymous_variant 0.75 rifampicin
rpoC 766963 c.3594T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767023 c.3654C>T synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 767044 c.3675G>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 767080 c.3711G>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 767107 c.3738C>T synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 767149 c.3780C>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 767179 c.3810C>T synonymous_variant 0.92 rifampicin
rpoC 767180 p.Ala1271Ser missense_variant 1.0 rifampicin Uncertain significance
rpoC 767191 c.3822C>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 767197 c.3828G>A synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 767203 c.3834C>G synonymous_variant 1.0 rifampicin
rpoC 767206 c.3837C>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 1.0 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpsL 781595 c.36T>C synonymous_variant 0.92 streptomycin
rpsL 781608 p.Ser17Ala missense_variant 0.92 streptomycin
rpsL 781616 c.57C>G synonymous_variant 0.92 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.93 streptomycin Not assoc w R - Interim
rpsL 781649 c.90T>C synonymous_variant 0.92 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.92 streptomycin
rpsL 781658 c.99A>C synonymous_variant 0.92 streptomycin Not assoc w R - Interim
rpsL 781802 c.243G>C synonymous_variant 0.82 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.85 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.85 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.86 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.83 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.92 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 1.0 streptomycin
rpsL 781871 c.312G>C synonymous_variant 1.0 streptomycin
rpsL 781877 c.318T>A synonymous_variant 0.7 streptomycin
rpsL 781892 c.333A>G synonymous_variant 1.0 streptomycin
rrs 1471918 n.73A>T non_coding_transcript_exon_variant 0.24 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471922 n.78delT non_coding_transcript_exon_variant 0.89 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.92 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471931 n.87delA non_coding_transcript_exon_variant 0.94 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.96 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471938 n.93T>A non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471985 n.140T>C non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.95 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.44 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Uncertain significance
rrs 1472380 n.535G>C non_coding_transcript_exon_variant 0.78 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.9 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.95 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.96 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472612 n.767G>T non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472734 n.889C>T non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472741 n.896G>A non_coding_transcript_exon_variant 0.76 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472846 n.1001C>T non_coding_transcript_exon_variant 0.95 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>A non_coding_transcript_exon_variant 0.95 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472848 n.1003T>C non_coding_transcript_exon_variant 0.95 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472860 n.1015C>T non_coding_transcript_exon_variant 0.96 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472861 n.1016G>A non_coding_transcript_exon_variant 0.96 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.62 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.61 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473082 n.1237G>A non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.95 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.44 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.52 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.41 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473288 n.1443C>T non_coding_transcript_exon_variant 0.56 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 1.0 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.44 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473291 n.1446G>T non_coding_transcript_exon_variant 0.56 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.44 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473291 n.1446G>T non_coding_transcript_exon_variant 0.56 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473717 n.60G>A non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473731 n.74T>A non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473746 n.89T>C non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid
rrl 1473756 n.99G>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid
rrl 1473770 n.113T>C non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473812 n.155G>A non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid
rrl 1473814 n.157A>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1473815 n.158T>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1473829 n.172G>C non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid
rrl 1473831 n.174G>T non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1473839 n.182G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474130 n.473C>T non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524_525insT non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1474184 n.527C>A non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1474185 n.529delA non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474263 n.606G>A non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid
rrl 1474282 n.625G>A non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474638 n.981C>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474639 n.982G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474640 n.983C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474709 n.1052_1060delGTGGTGTAAinsAATAAGTTAG non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1474722 n.1065T>C non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid
rrl 1474743 n.1086T>G non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475076 n.1419C>A non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475090 n.1433A>T non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475120 n.1463G>T non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid
rrl 1475129 n.1472G>A non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475202 n.1545G>C non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>A non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1475443 n.1786G>A non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475475 n.1818C>T non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid
rrl 1475479 n.1822C>T non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475480 n.1823A>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475573 n.1916G>A non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid
rrl 1475649 n.1992A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475758 n.2101A>G non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475760 n.2105_2106delGC non_coding_transcript_exon_variant 0.85 capreomycin
linezolid
rrl 1475764 n.2107A>T non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1475765 n.2108A>T non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475989 n.2332T>C non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid
rrl 1475993 n.2336C>T non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476085 n.2428G>A non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476114 n.2457T>C non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476221 n.2564T>C non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.28 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476524 n.2867C>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.97 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.97 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.96 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1476666 n.3009C>T non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1674892 p.Asn231Asp missense_variant 0.9 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674903 c.702T>C synonymous_variant 0.9 ethionamide
isoniazid
inhA 1674904 p.Ala235Pro missense_variant 0.9 ethionamide
isoniazid
inhA 1674909 c.708G>A synonymous_variant 0.9 ethionamide
isoniazid
inhA 1674912 c.711G>C synonymous_variant 0.9 ethionamide
isoniazid
inhA 1674915 c.714C>G synonymous_variant 0.9 ethionamide
isoniazid
rpsA 1833724 c.183C>T synonymous_variant 1.0 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 1.0 pyrazinamide
rpsA 1833733 c.192C>G synonymous_variant 1.0 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 1.0 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 1.0 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.92 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.92 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.93 pyrazinamide Not assoc w R - Interim
rpsA 1833787 c.246C>G synonymous_variant 0.87 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.87 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.79 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.79 pyrazinamide
rpsA 1833823 c.282G>A synonymous_variant 0.71 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.79 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.8 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.81 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.88 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.9 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.91 pyrazinamide
rpsA 1833874 c.333T>G synonymous_variant 0.92 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.92 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.96 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 1.0 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 1.0 pyrazinamide
rpsA 1833961 c.420C>G synonymous_variant 1.0 pyrazinamide
rpsA 1833970 c.429G>T synonymous_variant 1.0 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.91 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.91 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 0.93 pyrazinamide Not assoc w R - Interim
rpsA 1834294 c.753G>T synonymous_variant 0.94 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.93 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.94 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.94 pyrazinamide
rpsA 1834327 c.786G>T synonymous_variant 0.95 pyrazinamide
rpsA 1834357 c.816T>C synonymous_variant 0.91 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.91 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>C synonymous_variant 0.81 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.72 pyrazinamide
rpsA 1834477 c.936C>T synonymous_variant 0.64 pyrazinamide Not assoc w R - Interim
rpsA 1834489 c.948T>C synonymous_variant 0.8 pyrazinamide
rpsA 1834519 c.978G>C synonymous_variant 0.8 pyrazinamide
rpsA 1834520 c.979_981delGCCinsTG frameshift_variant&missense_variant 0.8 pyrazinamide Uncertain significance
rpsA 1834528 c.987T>C synonymous_variant 0.92 pyrazinamide
rpsA 1834534 c.993C>T synonymous_variant 0.91 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.92 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.92 pyrazinamide
rpsA 1834552 c.1011G>T synonymous_variant 0.91 pyrazinamide
rpsA 1834555 c.1014T>G synonymous_variant 0.92 pyrazinamide
rpsA 1834557 p.Ala339Gly missense_variant 0.92 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.92 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.92 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.9 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.9 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.93 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.93 pyrazinamide
rpsA 1834645 c.1104C>T synonymous_variant 0.94 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 1.0 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 1.0 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834700 p.Gln387Ala missense_variant 1.0 pyrazinamide
rpsA 1834705 c.1164C>G synonymous_variant 1.0 pyrazinamide
rpsA 1834720 c.1179C>G synonymous_variant 0.92 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.93 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.94 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.93 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.93 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.93 pyrazinamide
rpsA 1834774 c.1233C>T synonymous_variant 0.92 pyrazinamide
rpsA 1834776 p.Ala412Glu missense_variant 0.92 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.92 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.92 pyrazinamide
rpsA 1834813 c.1272G>T synonymous_variant 0.92 pyrazinamide
kasA 2517917 c.-198G>C upstream_gene_variant 0.9 isoniazid
kasA 2517941 c.-174C>G upstream_gene_variant 0.85 isoniazid
kasA 2517953 c.-162C>T upstream_gene_variant 0.83 isoniazid
kasA 2517959 c.-156C>T upstream_gene_variant 0.82 isoniazid
kasA 2517962 c.-153C>G upstream_gene_variant 0.8 isoniazid
kasA 2517968 c.-147T>A upstream_gene_variant 0.73 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.73 isoniazid
lpqB 3625783 c.-873C>T upstream_gene_variant 0.9 bedaquiline
rifampicin
mtrB 3625806 c.808A>C synonymous_variant 0.9 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625807 c.807C>G synonymous_variant 0.9 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625813 c.801C>T synonymous_variant 0.9 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3626704 c.-91C>T upstream_gene_variant 0.92 bedaquiline
rifampicin
mtrB 3626711 c.-98T>C upstream_gene_variant 0.92 bedaquiline
rifampicin
mtrB 3626717 c.-104C>T upstream_gene_variant 0.93 bedaquiline
rifampicin
mtrB 3626726 c.-113T>C upstream_gene_variant 0.93 bedaquiline
rifampicin
mtrB 3626732 c.-119A>G upstream_gene_variant 0.93 bedaquiline
rifampicin
mtrA 3626741 c.609C>G synonymous_variant 0.94 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626756 c.594C>G synonymous_variant 0.94 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626759 c.591T>C synonymous_variant 0.93 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626762 c.588G>C synonymous_variant 0.93 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626786 c.564A>G synonymous_variant 0.93 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626792 c.558G>T synonymous_variant 0.92 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627068 c.282T>C synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627073 c.277C>T synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrA 3627098 c.252A>C synonymous_variant 0.91 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>T upstream_gene_variant 0.91 bedaquiline
rifampicin
mtrB 3627110 c.-497G>C upstream_gene_variant 0.91 bedaquiline
rifampicin
rpoA 3877545 c.963G>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877554 c.954G>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877560 c.948C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877563 c.945C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877569 c.937_939delCCGinsAC frameshift_variant&missense_variant 1.0 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877593 c.915C>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoA 3877614 c.894G>A synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoA 3877620 c.888G>A synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoA 3877638 c.870T>C synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoA 3877856 c.652T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoA 3877896 c.612G>A synonymous_variant 0.94 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoA 3877929 c.577_579delATCinsGG frameshift_variant&missense_variant 0.94 rifampicin
rpoA 3878205 c.303T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
clpC1 4038782 c.1923G>T synonymous_variant 1.0 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038795 p.Ser637Thr missense_variant 1.0 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 1.0 pyrazinamide
clpC1 4038815 c.1890G>T synonymous_variant 1.0 pyrazinamide
clpC1 4038838 c.1867C>T synonymous_variant 0.88 pyrazinamide
clpC1 4038845 c.1858_1860delTCGinsAGC synonymous_variant 0.87 pyrazinamide
clpC1 4038857 c.1848C>G synonymous_variant 0.88 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 1.0 pyrazinamide
clpC1 4038911 c.1794G>C synonymous_variant 0.9 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.8 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.85 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.83 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.82 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.82 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.83 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.7 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.7 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.83 pyrazinamide
clpC1 4039046 c.1659C>G synonymous_variant 0.7 pyrazinamide
clpC1 4039070 c.1635G>C synonymous_variant 0.73 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.8 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.8 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.93 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.93 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.93 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.93 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.93 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.93 pyrazinamide
clpC1 4039190 c.1515C>T synonymous_variant 1.0 pyrazinamide
clpC1 4039196 c.1509G>A synonymous_variant 1.0 pyrazinamide
clpC1 4039220 c.1485G>C synonymous_variant 0.86 pyrazinamide
clpC1 4039304 c.1401G>A synonymous_variant 0.73 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039619 c.1086G>A synonymous_variant 0.79 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 1.0 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.83 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 1.0 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.94 pyrazinamide
clpC1 4039733 c.972G>A synonymous_variant 0.87 pyrazinamide
clpC1 4039739 c.966C>G synonymous_variant 0.77 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.83 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.8 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.8 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.82 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.6 pyrazinamide
clpC1 4039763 c.942C>T synonymous_variant 0.67 pyrazinamide Not assoc w R - Interim
clpC1 4039769 c.936C>G synonymous_variant 0.86 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.85 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.83 pyrazinamide
clpC1 4039814 c.891C>G synonymous_variant 0.83 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.83 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.83 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.64 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.92 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.92 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.94 pyrazinamide
clpC1 4039868 c.837C>T synonymous_variant 0.76 pyrazinamide Not assoc w R - Interim
clpC1 4039913 c.792C>T synonymous_variant 0.68 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.76 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.75 pyrazinamide
clpC1 4039943 c.762G>C synonymous_variant 0.6 pyrazinamide
clpC1 4039946 c.759A>G synonymous_variant 0.67 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.71 pyrazinamide
clpC1 4039957 c.748C>T synonymous_variant 0.54 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.58 pyrazinamide
clpC1 4039964 c.741C>G synonymous_variant 0.8 pyrazinamide
clpC1 4039975 p.Asp244Asn missense_variant 0.67 pyrazinamide Uncertain significance
clpC1 4039979 c.726C>G synonymous_variant 0.62 pyrazinamide
clpC1 4039982 c.723G>A synonymous_variant 0.79 pyrazinamide Not assoc w R - Interim
clpC1 4040009 c.696C>G synonymous_variant 0.64 pyrazinamide
clpC1 4040015 c.690G>C synonymous_variant 0.67 pyrazinamide
clpC1 4040021 c.684A>T synonymous_variant 0.82 pyrazinamide
clpC1 4040024 c.681A>G synonymous_variant 0.86 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.73 pyrazinamide
clpC1 4040048 c.657C>T synonymous_variant 0.76 pyrazinamide Not assoc w R - Interim
clpC1 4040087 c.618G>C synonymous_variant 0.7 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.7 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.7 pyrazinamide Not assoc w R - Interim
clpC1 4040480 c.225T>C synonymous_variant 0.92 pyrazinamide Not assoc w R - Interim
embC 4240741 c.879C>T synonymous_variant 0.7 ethambutol
embC 4240756 c.894G>C synonymous_variant 0.77 ethambutol
embC 4240771 c.909G>C synonymous_variant 0.67 ethambutol
embC 4240772 p.Ser304Ala missense_variant 0.67 ethambutol
embC 4240778 p.His306Gly missense_variant 0.67 ethambutol
embC 4240781 p.Ala307Ser missense_variant 0.67 ethambutol Uncertain significance
embC 4240789 c.927T>C synonymous_variant 0.62 ethambutol
embC 4240819 c.957A>C synonymous_variant 0.65 ethambutol
embC 4240826 p.Ala322Ser missense_variant 0.64 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.62 ethambutol