TB-Profiler result

Run: ERR9872306
Summary

Run ID: ERR9872306

Sample name:

Date: 2025-03-06T18:22:53.857088

Number of reads: 7830263

Percentage reads mapped: 99.98

Median coverage: 242.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: HR-TB

Download CSV Download TXT Download JSON
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.9 Euro-American (H37Rv-like) None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid katG c.1438_1440delGCG Mutation from literature
c.371delG Assoc w R High-level resistance
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
katG 2154671 c.1438_1440delGCG conservative_inframe_deletion 0.13 isoniazid Mutation from literature
katG 2155740 c.371delG frameshift_variant 0.27 isoniazid Assoc w R High-level resistance
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
katG 2154487 p.Asp542Gly missense_variant 0.21 isoniazid Uncertain significance
katG 2155594 p.Leu173Pro missense_variant 0.14 isoniazid Uncertain significance