TB-Profiler result

Run: ERR9125499
Summary

Run ID: ERR9125499

Sample name:

Date: 2025-03-06T10:13:15.456434

Number of reads: 1603720

Percentage reads mapped: 99.85

Median coverage: 82.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.9 Euro-American (H37Rv-like) None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7492 p.Phe64Ser missense_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
mmpL5 776528 p.Gln651His missense_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
ribD 2987070 p.Ala78Thr missense_variant 1.0 para-aminosalicylic_acid Uncertain significance
Rv3083 3449713 p.Ala404Thr missense_variant 1.0 ethionamide Uncertain significance
embC 4239509 c.-354G>A upstream_gene_variant 1.0 ethambutol Uncertain significance
embC 4242495 p.Asp878Ala missense_variant 1.0 ethambutol Uncertain significance
embB 4249334 p.Ala941Thr missense_variant 1.0 ethambutol Uncertain significance
ubiA 4269032 p.Gly268Ser missense_variant 1.0 ethambutol Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 amikacin Not assoc w R
capreomycin Not assoc w R
kanamycin Not assoc w R